Thursday, April 24th, 2014

LeptiBurn® – Scientific Research & Rationale

 

By Brett Hall, RD

 

The first thing that is important to note about the LeptiBurn formula is that it approaches the enhancement of leptin function and effectiveness from 4 completely different angles. They are:

    • Increasing leptin sensitivity in the brain;
    • Increasing leptin production in fat cells, independent of insulin;
    • Increasing the ability of leptin to cross the blood-brain barrier; and
    • Enhancing the physiological effects of leptin through increasing its activating co-factor amylin.

 

 

Simply put, no other product is approaching leptin function enhancement from all of these angles, especially enhancing amylin production.

On top of the leptin effects of LeptiBurn, it also provides the following fat loss benefits:

  • Slows the conversion of blood sugar to fat;
  • Increases insulin sensitivity;
  • Interferes with sugar absorption in the intestine;
  • Increases adiponectin levels;
  • Increases thyroid stimulating hormone (TSH);
  • Increases fatty acid oxidation (fat burning in fat cells); and
  • Decreases Neuropeptide Y (potent appetite stimulant in the brain).

The following is a description of how the ingredients in LeptiBurn® contribute to these effects.

Irvingia Gabonensis

  • Irvingia gabonensis is a fruit that grows in Cameroon, in West Africa. Locals call it “Bush Mango.” For centuries the indigenous people there have used the seed of the fruit in a soup they eat every day. Researchers noted a lack of all heart disease and obesity in this population. Thus began the research into the anti-obesity properties of the seed.
  • A recent study shows that Irvingia gambonensis extract enhances leptin sensitivity by decreasing levels of C-Reactive Protein (CRP) by an amazing 52%. CRP interferes with leptin’s anti-obesity actions by binding to leptin in the blood stream, blocking leptin’s ability to cross the blood-brain barrier and bind to the hypothalamus and signal satiety.2
  • A subsequent study, enlisting 102 human subjects taking 150mg of the seed extract 2 times per day, showed that this increase in leptin sensitivity increased weight loss dramatically in test subjects. At the end of 10 weeks, the Irvingia group lost an average of 28 pounds (a 13.1% decrease in body weight), shed 6.7 inches from their waistline, and had reduced their total body fat by an average of 18.4%. Subjects taking the placebo lost only 3 pounds.1
  • Other effects include:
  • Decrease in ability of fat cells to convert blood sugar to fat, through its inhibitory effect on glycerol-3-phosphate dehydrogenase, an enzyme produced in adipocytes facilitating the conversion of blood glucose to triglycerides (fat).3
  • Increases in insulin sensitivity, via stimulation of adiponectin production.4
  • Interference with sugar absorption, secondary to its ability to inhibit amylase secretion.5 This decreases the amount of carbohydrates absorbed, limiting spikes in blood sugar that lead to fat storage.

Olive Leaf Extract (Oleanolic acid)

This compound, extracted from Olive Tree Leaves, has a stimulatory effect on a specific gut peptide called Glucagon-like Peptide-1 (GLP-1). Research shows that an oral dose of this extract can increase GLP-1 by 48%.9 GLP-1 is a highly biologically active peptide that sits at the top of a hormonal cascade controlling multiple aspects of metabolism. Increased levels of circulating GLP-1 have been shown to:

  • Dramatically increase the effectiveness of Leptin in signaling satiety in the brain. It does so through stimulation of Amylin production from the pancreas. Amylin is a peptide hormone that is co-secreted with insulin from beta-cells in the pancreas, in a 1:100 ratio.
  • Very recent research shows that “[a]mylin increased leptin binding within the ventromedial hypothalamus (VMN) by 35% and dorsomedial hypothalamus by 47% (both P < 0.05 vs. vehicle).” By doing so… ”[a]mylin/leptin co-infusion additively decreased food intake (by 26%) and reduced body weight (by 15%) and epididymal [belly] fat by 78%; (all P < 0.05 vs. all groups)”8 Amylin appears to work as a co-factor with leptin, essentially “activating” it. Even big pharma companies have been looking at synthetic amylin to help increase the effectiveness of their leptin analogs, and overcome leptin resistance in the obese population.
  • Enhance leptin production in fat cells, through its ability to stimulate insulin secretion from the pancreas. GLP-1 not only stimulates the beta-cells in the pancreas to acutely secrete more insulin, it also increases beta-cell mass and insulin gene expression, which will support the robust secretion of insulin (one of the main stimulators of leptin production) in the long run.
  • To quote one study: “In a 24-week randomized, double-blind, clinical proof-of-concept study in overweight/obese subjects, co-administration of recombinant human leptin and the amylin analog pramlintide elicited 12.7% mean weight loss, significantly more than was observed with either treatment alone (P < 0.01).” AND, “These findings provide both nonclinical and clinical evidence that amylin agonism restored leptin responsiveness in diet-induced obesity, suggesting that integrated neurohormonal approaches to obesity pharmacotherapy may facilitate greater weight loss by harnessing naturally occurring synergies.”6
  • And another: “In obese humans, combination treatment with amylin/leptin analogs led to an approximately 13% weight loss after 24 weeks, significantly more than after treatment with amylin or leptin alone. Collectively, these findings suggest that combined amylin/leptin agonism may have therapeutic utility as part of an integrated, neurohormonal approach to obesity pharmacotherapy.”

Brown Seaweed Extract

The brown seasweed extract used in LeptiBurn® is harvested from pristine arctic waters off the coast of Iceland and processed under strict FDA and GMP guidelines and takes 40 lbs of seaweed to make a single pound of extract:

  • A recent study showed that “Short-term dietary supplementation with kelp significantly increases both basal and post-stimulation TSH (thyroid stimulating hormone).”10
  • Very recent research shows that by increasing circulating TSH levels in human subjects, leptin production in fat cells can be increased by up to 18%.11
  • Brown seaweed also contains high levels of a substance called Fucoxanthin, which has received much attention as an anti-obesity nutrient recently. From a review study done in 201112, researchers found that fucoxanthin was able to lower circulating leptin levels (presumably through enhancing absorption and utilization in the brain) and to increase adiponectin levels. Multiple other fat loss effects are attributed to fucoxanthin as well, including down-regulation of fat producing enzymes and up-regulation of fatty acid oxidation.

Panax Notoginseng

  • Panax notoginseng is a well-known and commonly used traditional Chinese herb, called “Shan Qi” by master herbalists, for the treatment of various diseases, such as hemostasis, edema and odynolysis. It is grown near mountain springs in southwestern China.
  • When researchers began looking at the metabolic effects of this special ginseng extract they noted that it lowered leptin levels, reduced food intake, increased weight loss, decreased Neuropeptide Y (which stimulates appetite), and increased cholecystokinin (appetite suppressant).13
  • Further research concluded that the lower leptin levels were due to an increase in leptin sensitivity and utilization in the brain. Researchers state, “Panax notoginseng extract possess anti-hyperglycemic and anti-obese activities by improving insulin—and leptin sensitivity.”14

Green Tea & Yerba Mate

LeptiBurn® uses a dual source of caffeine, 75% from green tea and 25% from Yerba mate. They each have their own unique weight loss properties.

  • Green tea extract standardized from caffeine has been shown in multiple studies to facilitate fat loss. Researchers in a very recent study summarized these effects in the following way: “A green tea-caffeine mixture improves weight maintenance, through thermogenesis, fat oxidation, and sparing fat free mass.”15
  • The other source of caffeine comes from a unique herb called Yerba mate. Yerba mate tea is made from the leaves of Ilex paraguariensis grown the rainforests of South America. Very recent research shows that an extract of yerba mate can induce significant weight loss, and that weight loss is due to the herb’s ability to increase GLP-1 and Leptin levels. Here is what researchers concluded in the study: “These findings suggest that mate may induce anorexic effects by direct induction of satiety and by stimulation of GLP-1 secretion and modulation of serum leptin levels.”16

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